Emigration and association

Chemorepulsion and thymocyte emigration.

The possibility that chemorepulsion, or cell migration away from a stimulus, plays a role in the immune system is exciting from both clinical and cellbiological viewpoints. For the clinician, what could be a more satisfying way to treat a cell-mediated immune disease than local application of a chemorepellent? For the cell biologist, eukaryotic cell chemorepulsion represents a novel behavior to...

Thymic emigration revisited

Conventional alphabeta T cell precursors undergo positive selection in the thymic cortex. When this is successful, they migrate to the medulla and are exposed to tissue-specific antigens (TSA) for purposes of central tolerance, and they undergo maturation to become functionally responsive T cells. It is commonly understood that thymocytes spend up to 2 wk in the medulla undergoing these final m...

Textual Emigration Analysis

We present a web-based application which is called TEA (Textual Emigration Analysis) as a showcase that applies textual analysis for the humanities. The TEA tool is used to transform raw text input into a graphical display of emigration source and target countries (under a global or an individual perspective). It provides emigration-related frequency information, and gives access to individual ...

Antigen challenge inhibits thymic emigration.

T cell development in the thymus involves a series of TCR-mediated control points including TCR-beta selection and positive and negative selection. Approximately half of the thymic sojourn is spent in the medulla, where thymocytes undergo final maturation before emigrating to the periphery. Although it is acknowledged that thymic emigration is an active process, relatively little is known about...

Thymic Emigration: When and How T Cells